SYNTHESIS OF ZINC SULFIDE NANOPARTICLES AND CONJUGATION WITH FOLATE AND SORAFENIB DRUG FOR THE TREATMENT OF HEPATOCELLULAR CARCINOMA

Abstract

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. It is a cancer that originates in the hepatocytes, which are the main functional cells of the liver. HCC typically develops in the context of chronic liver diseases, such as cirrhosis (scarring of the liver tissue) or chronic hepatitis B or C infection. In its early stages, HCC may not cause noticeable symptoms. As the cancer progresses, symptoms may include abdominal pain or discomfort, unexplained weight loss, jaundice, fatigue, and a feeling of fullness in the abdomen. Treatment options for HCC depend on the stage of the cancer and the overall health of the patient. They may include, radiation therapy, targeted therapy, immunotherapy, and in some cases, chemotherapy. Liver transplantation can be curative for early-stage HCC in select patients.